What Are the Implications of the Fenton Reaction in Drug Toxicity?
Some drugs can induce oxidative stress by increasing the production of ROS or by disrupting the balance of redox-active metals like iron. For example, certain chemotherapeutic agents and non-steroidal anti-inflammatory drugs (NSAIDs) are known to enhance ROS formation, partly through the Fenton reaction. Understanding the role of the Fenton reaction in drug toxicity can aid in developing strategies to mitigate adverse effects, such as using iron chelators or antioxidant co-therapies to reduce oxidative stress.
