fenton reaction

How Do Iron Levels Affect the Fenton Reaction?

Iron is a critical factor in the Fenton reaction. The availability of ferrous iron (Fe2+) is a limiting factor for the production of hydroxyl radicals. Conditions that lead to increased levels of free iron, such as iron overload disorders (e.g., hemochromatosis), can enhance the Fenton reaction, increasing oxidative stress and potential toxicity.
Conversely, the body regulates iron through a complex network of proteins, such as ferritin and transferrin, to minimize free iron and reduce the risk of Fenton-mediated damage.

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