Why is the Fenton Reaction Important in Toxicology?
The Fenton reaction is of particular interest in toxicology because it is a major source of reactive oxygen species (ROS) within cells. These ROS can lead to oxidative stress, a condition in which the production of free radicals exceeds the body's ability to neutralize them, potentially resulting in cellular damage and death. Key health issues linked to oxidative stress include cancer, neurodegenerative diseases like Alzheimer's and Parkinson's, cardiovascular diseases, and aging. The Fenton reaction is also implicated in the toxicity of certain environmental pollutants and drugs that increase intracellular iron or hydrogen peroxide levels.
