What are the Key Components of Preclinical Toxicity Testing?
Preclinical toxicity testing typically involves several components, including acute toxicity, subacute and chronic toxicity studies, reproductive and developmental toxicity, genotoxicity, and carcinogenicity assessments. Acute toxicity tests determine the effects of a single high dose of a compound and help in identifying potential target organs. Subacute and chronic toxicity studies provide information on the effects of repeated exposure over weeks or months. Reproductive and developmental toxicity tests assess the impact on fertility and embryonic development.
