The primary endpoints in AR assays include binding affinity, agonist activity, and antagonist activity. Binding affinity measures how strongly a compound binds to the androgen receptor. Agonist activity assesses whether the compound can activate the receptor, mimicking the action of natural androgens. Antagonist activity evaluates whether the compound inhibits the receptor, blocking the effect of natural androgens. These endpoints help determine the potential endocrine-disrupting effects of the test compound.