What Are the Key Mechanisms of Proteostasis Regulation?
Proteostasis is regulated by several key mechanisms:
Chaperones: These proteins assist in the proper folding and assembly of other proteins. Proteasomes: Proteasomes degrade misfolded or damaged proteins to prevent their accumulation. Autophagy: This process involves the degradation of cellular components, including proteins, through lysosomal pathways. Unfolded Protein Response (UPR): This cellular stress response is activated by the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum.
