What Are the Mechanisms Behind Lipodystrophy Induced by Drugs?
The mechanisms by which drugs induce lipodystrophy are complex and multifactorial. They may involve mitochondrial toxicity, oxidative stress, and direct effects on adipocytes. For example, protease inhibitors, a class of antiretroviral drugs, have been linked to mitochondrial dysfunction, which can lead to fat redistribution. Additionally, these drugs may interfere with adipocyte differentiation and function.
