taxanes

What Are the Mechanisms Behind Taxane Toxicity?

The toxic effects of taxanes are primarily due to their action on normal, rapidly dividing cells, such as those in the bone marrow, hair follicles, and gastrointestinal tract. The stabilization of microtubules affects not only cancer cells but also these normal cells, leading to side effects. Additionally, taxanes can cause oxidative stress and mitochondrial dysfunction, further contributing to their toxic profile.

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