dna damaging agents

What Are the Mechanisms of DNA Damage?

DNA damage can occur through various mechanisms, including:
Base Modifications: Alterations in the normal structure of DNA bases, such as deamination or oxidation, can lead to incorrect base pairing during replication.
Single-Strand Breaks: Breaks in one of the DNA strands can be caused by oxidative stress or certain chemical agents.
Double-Strand Breaks: These are more severe than single-strand breaks and can result from ionizing radiation or certain chemotherapeutic drugs.

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