What Are the Potential Benefits of Nrf2 Activators?
The activation of Nrf2 has been linked to numerous health benefits, primarily due to its ability to upregulate a wide array of protective genes. These benefits include:
- Reduction of oxidative stress: By inducing the expression of antioxidant enzymes like glutathione peroxidase and catalase, Nrf2 activators help to neutralize free radicals and reduce oxidative damage. - Detoxification: Nrf2 activators increase the expression of phase II detoxifying enzymes such as glutathione S-transferases, aiding in the removal of toxic substances from the body. - Anti-inflammatory effects: By modulating the expression of pro-inflammatory cytokines, Nrf2 activators can help in reducing inflammation. - Cytoprotection: These activators enhance the cell's ability to repair and regenerate, which is crucial in preventing damage from toxic exposures.
