Are There Any Risks Associated with Nrf2 Activators?
While Nrf2 activators have numerous potential benefits, there are also concerns regarding their long-term use:
- Cancer Risk: Some studies suggest that chronic activation of Nrf2 can lead to enhanced cell survival, which might contribute to cancer progression, especially in already malignant cells. - Disruption of normal cellular processes: Overactivation of Nrf2 may interfere with normal cell apoptosis and other cellular processes, leading to unintended consequences. - Resistance to chemotherapy: In certain cases, Nrf2 overactivation can result in the development of resistance to chemotherapy drugs, complicating cancer treatment.
