What are the Strategies to Mitigate Toxicity from Reactive Metabolites?
Several strategies can be employed to reduce the toxic effects of reactive metabolites:
Drug Design: Modifying the chemical structure of drugs to minimize the formation of reactive intermediates. Use of Antioxidants: Co-administration of antioxidants to scavenge ROS and reduce oxidative stress. Enzyme Inhibition: Inhibiting specific metabolic enzymes to prevent the formation of harmful metabolites. Monitoring and Dose Adjustment: Regular monitoring of drug levels and adjusting doses accordingly to prevent accumulation of toxic metabolites.
