Which Compounds are Known to Form Reactive Metabolites?
A variety of compounds are known to produce reactive metabolites. Examples include:
Acetaminophen: Overdose can lead to the formation of a toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), causing liver damage. Antibiotics such as isoniazid: Metabolism can produce reactive intermediates that may lead to liver toxicity. Polycyclic aromatic hydrocarbons (PAHs): Found in tobacco smoke, these can be metabolized into reactive epoxides with carcinogenic potential.
