How Can the Formation of Reactive Metabolites be Predicted?
Predicting the formation of reactive metabolites involves several strategies:
In Silico Models: Computational models can predict the likelihood of reactive metabolite formation based on the chemical structure of compounds. In Vitro Studies: Using liver microsomes or hepatocytes to study the metabolic pathways and identify potential reactive intermediates. Structure-Activity Relationships (SAR): Analyzing chemical structures known to form reactive metabolites to identify similar potential candidates.
