What are the Strategies to Prevent Aminoglycoside Toxicity?
To prevent toxicity, it is essential to use aminoglycosides judiciously and only when necessary. Dose adjustments based on renal function, proper hydration, and avoiding concurrent use of other nephrotoxic agents can reduce the risk of nephrotoxicity. Monitoring drug levels and adjusting doses accordingly is critical. Limiting the duration of therapy and considering alternative antibiotics when possible are also important strategies. In some cases, the use of protective agents like N-acetylcysteine has been explored to mitigate nephrotoxicity.
