What are the Risk Factors for Aminoglycoside Toxicity?
Several factors increase the risk of aminoglycoside toxicity, including age (both very young and elderly patients), concurrent use of other nephrotoxic or ototoxic drugs, dehydration, and prolonged therapy. Pre-existing renal impairment also significantly increases the risk of nephrotoxicity. Genetic predispositions, such as mitochondrial mutations, can predispose individuals to ototoxicity even at low doses.
