What are the Toxicological Concerns of COX Inhibitors?
The toxicity of COX inhibitors is a significant concern in toxicology. Non-selective NSAIDs can cause gastrointestinal toxicity, such as ulcers and bleeding, due to the inhibition of COX-1, which plays a protective role in the gastric lining. Selective COX-2 inhibitors, while reducing gastrointestinal risks, have been linked to an increased risk of cardiovascular events, such as heart attacks and strokes, due to their effects on vascular homeostasis.
