How do Genetic Variations Affect COX-Related Toxicity?
Genetic variations can significantly influence the metabolism and toxicity of COX inhibitors. Polymorphisms in genes encoding COX enzymes or related metabolic pathways can alter drug efficacy and toxicity. For example, individuals with certain genetic variants may be more susceptible to the adverse effects of NSAIDs or exhibit varied responses in terms of efficacy and safety. Pharmacogenomics, the study of how genes affect a person's response to drugs, is increasingly important in tailoring safer and more effective therapeutic strategies.
