What is the Role of COX in Drug-Induced Liver Injury?
Drug-induced liver injury (DILI) is a critical aspect of toxicology associated with the use of certain medications, including NSAIDs. The involvement of COX enzymes in DILI is complex and often involves a combination of direct hepatotoxicity and immune-mediated mechanisms. The overproduction of reactive oxygen species (ROS) and the formation of toxic metabolites can exacerbate liver damage. Understanding the role of COX in these processes is crucial for assessing liver toxicity and developing safer therapeutic options.
