How Can Transcription Factors Be Targeted for Therapeutic Purposes?
Targeting transcription factors can be a promising strategy for developing therapies against toxicant-induced damage. For instance, modulating the activity of Nrf2 can enhance the cellular antioxidant capacity, providing protection against oxidative damage. Similarly, inhibiting NF-κB can reduce inflammation and tissue damage in response to toxic exposure. Researchers are investigating various small molecules and biologics that can specifically target these transcription factors to mitigate the adverse effects of toxins.
