What are the Toxicological Implications of Kinase Inhibition?
Inhibiting specific kinases can have therapeutic benefits, particularly in diseases where they are overactive. However, kinase inhibitors can also lead to unintended toxicological consequences. For example, inhibiting kinases involved in essential physiological functions may result in adverse effects such as cardiotoxicity or hepatotoxicity. Therefore, understanding the specific roles of kinases in different tissues and conditions is crucial for developing safe and effective kinase-targeting drugs.
