What is the Relationship Between PXR and Other Nuclear Receptors?
PXR does not operate in isolation; it interacts with other nuclear receptors such as the constitutive androstane receptor (CAR) and the aryl hydrocarbon receptor (AhR). This interplay can fine-tune the body's response to xenobiotics. For instance, PXR and CAR often regulate overlapping sets of genes, but they can also have distinct effects depending on the ligand and tissue context. This crosstalk is crucial for maintaining homeostasis in the face of chemical challenges.
