In toxicology, ascites can arise from exposure to various toxins and chemicals that impact organ function, particularly the liver. The liver plays a crucial role in metabolizing toxins, and its impairment can lead to fluid retention. Some of the toxicological causes of ascites include:
Hepatotoxicity: Exposure to substances like alcohol, certain drugs (e.g., acetaminophen), and industrial chemicals can lead to liver damage. Damaged liver cells may cause increased pressure in the portal vein, resulting in fluid leakage into the peritoneal cavity. Nephrotoxicity: Toxins that affect kidney function can also lead to fluid retention and ascites. Impaired kidneys may fail to excrete excess fluid, contributing to its accumulation in the abdomen. Cardiotoxicity: Certain toxins can affect heart function, leading to heart failure and subsequent ascites due to increased venous pressure.
