Methotrexate toxicity can occur due to high doses, prolonged use, or drug interactions that increase its concentration in the body. Factors such as renal impairment, dehydration, or concurrent use of nephrotoxic drugs can also elevate the risk. Patients with impaired liver function or those taking medications like nonsteroidal anti-inflammatory drugs (NSAIDs) should be cautious, as these can exacerbate toxicity.
