What are the Treatment Options for Methotrexate Toxicity?
The primary goal of treating methotrexate toxicity is to reduce its concentration in the body and manage symptoms. Leucovorin rescue therapy is crucial, as it provides a folate source to counteract methotrexate's effects. In severe cases, glucarpidase can be administered to rapidly decrease methotrexate levels. Supportive care, including hydration, electrolyte correction, and symptomatic treatment, is necessary. Dialysis may be considered in life-threatening situations.
