Complexity of Mixtures: Real-world mixtures can contain hundreds or thousands of chemicals, making it difficult to isolate and study specific interactions. Limited Data: There is often insufficient data on the toxicological profiles of individual chemicals, let alone their interactions in mixtures. Regulatory Limitations: Current regulatory approaches may not fully account for the complexities of mixture effects, leading to potential underestimation of risks. Variability in Responses: Biological variability can lead to differences in how mixtures affect different organisms or even individuals within the same species.
