Several factors can influence ADME processes, including age, gender, genetic makeup, health status, and environmental factors. For instance, infants and the elderly may have different metabolic rates compared to healthy adults. Genetic polymorphisms can lead to variations in enzyme activity, affecting metabolism and excretion. Additionally, co-exposure to multiple chemicals, such as in occupational settings, can alter ADME processes. Recognizing these factors is important in personalized toxicology and for tailoring risk assessments to individual needs.
