ADME processes are studied using a combination of in vitro, in vivo, and in silico methods. In vitro studies use cell cultures to examine absorption and metabolism, while in vivo studies often involve animal models to explore the systemic effects of toxicants. Computational models and simulations (in silico) are increasingly used to predict ADME characteristics based on chemical structure and properties, providing valuable insights into potential toxicological outcomes.
In conclusion, the ADME processes are central to understanding the toxicological impact of substances in the body. By studying these processes, toxicologists can better predict and mitigate the adverse effects of toxicants, leading to improved safety assessments and therapeutic strategies.
