The activity of CYP2E1 can be influenced by genetic, environmental, and physiological factors. Genetic polymorphisms in the CYP2E1 gene can lead to variations in enzyme activity among individuals, impacting their susceptibility to toxicants. Environmental factors such as exposure to inducers like ethanol and tobacco smoke can upregulate CYP2E1 expression, increasing its metabolic capacity. Physiological factors, including hepatic function and hormonal changes, also modulate its activity.
