The role of CYP2E1 extends beyond drug metabolism to implications in disease pathogenesis. The enzyme's involvement in the metabolic activation of procarcinogens links it to cancer risk. Additionally, its role in generating reactive oxygen species (ROS) and promoting oxidative stress is associated with liver diseases such as alcoholic liver disease and non-alcoholic fatty liver disease (NAFLD). Understanding CYP2E1’s contribution to disease mechanisms is vital for developing therapeutic strategies.
