CYP2E1 plays a significant role in the pharmacokinetics of certain drugs by metabolizing them into less active or inactive forms, facilitating their excretion. However, this enzyme is also known for converting some drugs into more toxic metabolites, contributing to adverse drug reactions. For example, the conversion of acetaminophen to its toxic metabolite is primarily mediated by CYP2E1, highlighting its dual role in detoxification and activation.
