What is the Death-Inducing Signaling Complex (DISC)?
The death-inducing signaling complex (DISC) is a multi-protein complex crucial for the activation of the extrinsic pathway of apoptosis. It forms upon ligand binding to the death receptors on the cell surface, such as Fas or TNF-related apoptosis-inducing ligand (TRAIL) receptors. The DISC comprises several key proteins, including the death receptors, adaptor proteins like FADD, and initiator caspases such as caspase-8.
