Yes, dysregulation of DISC can significantly contribute to toxicity. When DISC activation is excessive or uncontrolled, it can lead to widespread apoptosis, causing tissue damage and organ failure. Conversely, inhibition of DISC can result in the survival of cells that should undergo apoptosis, leading to the accumulation of damaged cells and potential tumorigenesis. Therefore, maintaining a balance in DISC activity is crucial for preventing toxicological consequences.
