While PBPK modeling offers numerous advantages, it also presents several challenges: 1. Data Availability: Accurate physiological and chemical-specific data are required, which may not always be available. 2. Complexity: The complexity of biological systems makes it difficult to develop comprehensive models. 3. Validation: Ensuring the model accurately predicts real-world outcomes is challenging and requires extensive validation. 4. Inter-Individual Variability: Capturing the variability between individuals can be difficult due to the numerous factors influencing ADME processes.
