Neurotransmitters are central to the development of CINV. Serotonin, released from the enterochromaffin cells of the small intestine, binds to 5-HT3 receptors, leading to nausea and vomiting. Substance P, another crucial neurotransmitter, binds to NK1 receptors, playing a significant role in delayed CINV. Understanding these mechanisms helps in the development of targeted antiemetic therapies.
