substrates

What Role Do Substrates Play in Drug Metabolism?

In drug metabolism, substrates are often parent drugs that undergo enzymatic conversion to more water-soluble metabolites, facilitating their excretion. This process is primarily carried out by liver enzymes, such as Cytochrome P450 enzymes. These enzymes can be induced or inhibited by various substrates, altering the pharmacokinetics and toxicity of drugs. Understanding substrate interactions is essential for predicting potential drug-drug interactions.

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