What are the potential interactions of spironolactone?
Spironolactone has several potential interactions with other medications. As mentioned earlier, combining spironolactone with other agents that increase serum potassium levels can lead to hyperkalemia. Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the diuretic effect of spironolactone and increase the risk of nephrotoxicity. Spironolactone may also interact with digoxin, potentially increasing digoxin levels and the risk of toxicity. Monitoring and dose adjustments may be necessary when spironolactone is used with these drugs.
