What role do toxicokinetics and toxicodynamics play in risk assessment models?
Toxicokinetics and toxicodynamics are crucial in understanding how a chemical interacts with biological systems:
Toxicokinetics: This involves the study of absorption, distribution, metabolism, and excretion (ADME) of chemicals. It helps in determining the internal dose that reaches target tissues, which is critical for accurate dose-response assessments. Toxicodynamics: This focuses on the interaction of chemicals with cellular components and the subsequent biological effects. Understanding these interactions aids in identifying mechanisms of toxicity and potential biomarkers for exposure and effect.
