What Role Does ADP Ribosylation Play in Cellular Damage and Repair?
ADP ribosylation is involved in cellular response to damage, particularly in the repair of DNA strand breaks. Poly(ADP-ribose) polymerases (PARPs) are key enzymes that facilitate the addition of ADP-ribose polymers to proteins involved in DNA repair. This modification signals the recruitment of repair proteins to sites of damage. Inhibition of PARPs has been explored in cancer therapy, as cancer cells often rely more heavily on these repair pathways. However, dysregulation of ADP ribosylation can lead to cellular dysfunction and contribute to the pathology of various diseases.
