Smoking is a well-known risk factor for exposure to a variety of toxic substances, including nicotine, tar, and carbon monoxide. It can also enhance the metabolism of other toxicants, leading to increased formation of harmful metabolites. Smoking is associated with an elevated risk of developing cancers, respiratory diseases, and cardiovascular disorders, partly due to the synergistic effects of these toxicants. Additionally, smoking can impair the body's ability to detoxify other chemicals, exacerbating their toxic effects.