What role does the gastrointestinal tract play in barrier function?
The gastrointestinal tract is responsible for nutrient absorption but also serves as a barrier to potentially harmful substances. The intestinal epithelium acts as a selective filter, allowing nutrients to pass while blocking toxins. Specialized cells, such as goblet cells and Paneth cells, produce mucus and antimicrobial peptides that further protect the gut lining. However, certain toxins can disrupt this balance, leading to increased permeability and potential systemic exposure.
