Variability occurs due to a combination of factors:
1. Genetics: Genetic makeup can influence the metabolism and response to toxins. For instance, polymorphisms in genes encoding for cytochrome P450 enzymes can result in different metabolic rates. 2. Age: Sensitivity to toxins can vary with age. Children and the elderly are often more susceptible due to differences in metabolism and physiological functions. 3. Sex: Men and women may respond differently to toxins due to hormonal differences and variations in fat distribution. 4. Health Status: Pre-existing health conditions, such as liver or kidney disease, can affect an individual's ability to detoxify and excrete harmful substances. 5. Exposure History: Previous exposure to certain chemicals can lead to tolerance or sensitization, altering an individual's response to subsequent exposures.
