Why is NF-κB considered a double-edged sword in toxicology?
NF-κBâs role as a "double-edged sword" arises from its dual capability to promote cell survival and inflammation. On one hand, NF-κB activation can lead to the expression of genes that protect cells from apoptosis, potentially providing resistance against toxic damage. On the other hand, chronic NF-κB activation can result in excessive inflammation and has been linked to various diseases, including cancer, making its regulation a critical aspect in the study of toxicity mechanisms.
