Research on NF-κB in toxicology utilizes various techniques such as gene knockout models, reporter assays, and biochemical analyses to understand its activation pathways and effects. Advances in molecular biology and bioinformatics allow for a deeper exploration of NF-κBâs role in toxicological responses, including its interaction with other signaling pathways and its impact on gene expression profiles. These studies are crucial for developing targeted interventions in toxicology.
In conclusion, NF-κB serves as a central node in the response to toxic stress and plays a significant role in regulating inflammation, cell survival, and carcinogenesis. Its complex role in toxicology offers both challenges and opportunities for therapeutic intervention, making it a critical focus for ongoing research in the field.
