How does NF-κB contribute to chemical carcinogenesis?
In the context of chemical carcinogenesis, NF-κB facilitates the transcription of genes that promote cell proliferation and inhibit apoptosis, which can contribute to tumorigenesis. Exposure to carcinogens like polycyclic aromatic hydrocarbons or tobacco smoke can lead to persistent NF-κB activation, potentially resulting in the dysregulation of cell cycle control and the promotion of oncogenic pathways. This makes NF-κB a target of interest in cancer research and prevention strategies.
