Are There Any Known Chemical Exposures That Worsen Gorlin Syndrome?
Yes, certain chemical exposures are known to potentially exacerbate Gorlin Syndrome. For instance, exposure to arsenic compounds and ionizing radiation has been associated with increased rates of basal cell carcinoma in patients with NBCCS. These exposures can lead to DNA damage, which, when compounded with the genetic mutations present in Gorlin Syndrome, can significantly impact cellular health and promote tumorigenesis.
