Azole antifungals require special precautions in certain populations. For instance, they should be used with caution in patients with liver disease due to the risk of hepatotoxicity. In pregnant women, the use of azoles is generally avoided unless absolutely necessary, as some azoles, like fluconazole, have been associated with teratogenic effects. Regular monitoring of liver function tests and electrolyte levels can help in preventing and identifying early signs of toxicity.
