What are the Common Toxicities Associated with Azole Antifungals?
Despite their effectiveness, azole antifungals can cause several adverse effects. Hepatotoxicity is a significant concern, particularly with ketoconazole, which can lead to severe liver damage. Other potential toxicities include gastrointestinal disturbances, such as nausea and vomiting, as well as cardiovascular effects like QT prolongation. Monitoring is essential to mitigate these risks, especially in patients with pre-existing conditions or those on concurrent medications.
