Azoles inhibit the enzyme lanosterol 14α-demethylase, which is involved in converting lanosterol to ergosterol. By inhibiting this enzyme, azoles disrupt the synthesis of ergosterol, leading to increased membrane permeability and ultimately the death of the fungal cell. While effective, this mechanism of action can also lead to drug interactions, as the enzyme is part of the cytochrome P450 system that metabolizes various medications.
