What are the Drug Interactions with Azole Antifungals?
Due to their mechanism of action, azole antifungals are known to interact with a wide variety of medications. They can inhibit the metabolism of drugs that are substrates for the cytochrome P450 enzymes, leading to increased plasma concentrations and potential toxicity. It is vital to review a patient's medication list for possible interactions, particularly with drugs such as warfarin, statins, and certain immunosuppressants.
